Tg(Eno2-Bmp4)3Jake
Transgene Detail

Summary

• Symbol: Tg(Eno2-Bmp4)3Jake
• Name: transgene insertion 3, John A Kessler
• MGI ID: MGI:5515418
• Synonyms: NSE-BMP4
• Transgene: Tg(Eno2-Bmp4)3Jake Location: unknown
• Alliance: Tg(Eno2-Bmp4)3Jake page

Transgene origin

• Strain of Origin: (BALB/c x C57BL/6)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Eno2-Bmp4)3Jake expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Bmp4 (MGI:88180)

• Mutation details: The murine Bmp4 is under the control of the rat neuron-specific enolase (Eno2) promoter (containing the initial, noncoding exon which increases expression levels). Three lines were established; 1,2, and 3. Levels of Bmp4 mRNA are comparable in all three lines. BMP4 expression is first detectable by Western blot at E16 and the increase persists into adulthood. (J:82446)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:82446 Gomes WA, et al., Transgenic overexpression of BMP4 increases astroglial and decreases oligodendroglial lineage commitment. Dev Biol. 2003 Mar 1;255(1):164-77
• All: 6 reference(s)