Tg(Prnp-ATXN3*70Q)70.61Olri
Transgene Detail

Summary

• Symbol: Tg(Prnp-ATXN3*70Q)70.61Olri
• Name: transgene insertion 70.61, Olaf Riess
• MGI ID: MGI:5516451
• Transgene: Tg(Prnp-ATXN3*70Q)70.61Olri Location: unknown
• Alliance: Tg(Prnp-ATXN3*70Q)70.61Olri page

Transgene origin

• Strain of Origin: C57BL/6N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-ATXN3*70Q)70.61Olri expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ATXN3 (4287)

  Atxn3

  (MGI:1099442)

• Mutation details: The mouse prion promoter (containing 1140 bp of the prion protein gene upstream of exon 1, the complete exon 1, intron 1, and the first 52 bp of exon 2) drives the expression of the full-length human ATAXIN-3 (ATAXIN-3c isoform that contains an additional ubiquitin-interacting motif at its C terminus) containing 70 CAG repeats. Four lines were created: 70.42, 70.48, 70.61, and 70.66. (J:122993)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:122993 Bichelmeier U, et al., Nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3: in vivo evidence. J Neurosci. 2007 Jul 11;27(28):7418-28
• All: 2 reference(s)