Tg(Camk2a-HBEGF)BNKza
Transgene Detail
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Symbol: |
Tg(Camk2a-HBEGF)BNKza |
Name: |
transgene insertion B, Kazu Nakazawa |
MGI ID: |
MGI:5523547 |
Synonyms: |
DTRloxP, fDTR, fDTR-line-B |
Transgene: |
Tg(Camk2a-HBEGF)BNKza Location: unknown
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Alliance: |
Tg(Camk2a-HBEGF)BNKza page
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Transgene Type: |
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Transgenic (Conditional ready, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Camk2a-HBEGF)BNKza expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
HBEGF (1839) |
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Mutation details: A targeting construct contained the Camk2a promoter, a loxp flanked alkaline phosphates-pA stop cassette and the sequence for the human homolog of heparin-binding epidermal growth factor-like growth factor (HBEGF) which functions as a diphtheria toxin receptor (DTR) in mice. Lines A and B were generated with line B exhibiting reduced expression compared with line A. Upon cre-mediated excision of the floxed AP stop cassette, the DTR is expressed making it possible to ablate specific cell populations.
(J:197654)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:197654 Jinde S, et al., Hilar mossy cell degeneration causes transient dentate granule cell hyperexcitability and impaired pattern separation. Neuron. 2012 Dec 20;76(6):1189-200 |
All: |
1 reference(s) |
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