Tg(Snca-SNCA)#Galt
Transgene Detail

Summary

• Symbol: Tg(Snca-SNCA)#Galt
• Name: transgene insertion, Dagmar Galter
• MGI ID: MGI:5526031
• Transgene: Tg(Snca-SNCA)#Galt Location: unknown
• Alliance: Tg(Snca-SNCA)#Galt page

Transgene origin

• Strain of Origin: C57BL/6 x DBA/2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Snca-SNCA)#Galt expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SNCA (6622)

  Snca	(MGI:1277151)

• Mutation details: 7 kb of the mouse alpha-synuclein promoter drives the expression of a human alpha-synuclein cDNA. Northern blot, in-situ hybridization and Western blot confirmed expression of the transgene. Two lines were generated and the pound symbol (#) is used when line is not specified and/or lines are pooled. (J:142519)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:142519 Westerlund M, et al., Lrrk2 and alpha-synuclein are co-regulated in rodent striatum. Mol Cell Neurosci. 2008 Dec;39(4):586-91
• All: 3 reference(s)