Tg(tetO-PIK3CA*H1047R,-luc)2239Jjz
Transgene Detail

Summary

• Symbol: Tg(tetO-PIK3CA*H1047R,-luc)2239Jjz
• Name: transgene insertion 2239, Jean J Zhao
• MGI ID: MGI:5526971
• Synonyms: HR-2239, TetOp-HA-PIK3CA-H1047R-luciferase, TetO-PIK3CA^H1047R
• Transgene: Tg(tetO-PIK3CA*H1047R,-luc)2239Jjz Location: unknown
• Alliance: Tg(tetO-PIK3CA*H1047R,-luc)2239Jjz page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence, Reporter)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-PIK3CA*H1047R,-luc)2239Jjz expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PIK3CA (5290)

  Pik3ca

  (MGI:1206581)

• Mutation details: The human PIK3CA cDNA with an amino acid substitution of arginine for histidine at position 1047 (H1047R) and an IRES-luciferase reporter are under the control of a tetracycline-inducible promoter. Two lines were generated, HR-2239 and HR-2251. (J:175839)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(tetO-PIK3CA*H1047R,-luc)2239Jjz

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:175839 Liu P, et al., Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway-dependent and PI3K pathway-independent mechanisms. Nat Med. 2011;17(9):1116-20
• All: 7 reference(s)