Tg(Alb-Mut)#Cpv
Transgene Detail

Summary

• Symbol: Tg(Alb-Mut)#Cpv
• Name: transgene insertion, Charles P Venditti
• MGI ID: MGI:5527452
• Synonyms: Tg^INS-Alb-Mut
• Transgene: Tg(Alb-Mut)#Cpv Location: unknown
• Alliance: Tg(Alb-Mut)#Cpv page

Enlarged mitochondria with whorl-like cristae in Mmut^tm1Cpv/Mmut^tm1Cpv Tg(Alb-Mut)#Cpv/0 mice fed a high-protein diet

Show the 3 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Alb-Mut)#Cpv expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Mmut (MGI:97239)

• Mutation details: This transgene construct contains a 2.25 kb murine Mut cDNA under the control of an alpha-fetoprotein enhancer and murine minimal albumin promoter cloned between two full-length tandem repeated chromatin barrier [hypersensitive site 4 from the chicken beta-globin cluster locus control region (cHS4)] insulator elements. Three founder lines were established. This represents the lowest expressing line. The pound symbol (#) is used because the line number is not specified. (J:200689)

Schematic of the Tg(Alb-Mut)#Cpv transgene

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:200689 Manoli I, et al., Targeting proximal tubule mitochondrial dysfunction attenuates the renal disease of methylmalonic acidemia. Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13552-7
• All: 3 reference(s)