Tg(Myh6-ACTC1*E99K)#Sbm
Transgene Detail

Summary

• Symbol: Tg(Myh6-ACTC1*E99K)#Sbm
• Name: transgene insertion, Steven B Marston
• MGI ID: MGI:5543406
• Synonyms: ACTC E99K
• Transgene: Tg(Myh6-ACTC1*E99K)#Sbm Location: unknown
• Alliance: Tg(Myh6-ACTC1*E99K)#Sbm page

Transgene origin

• Strain of Origin: (C57BL/10 x CBA/Ca)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-ACTC1*E99K)#Sbm expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ACTC1 (70)

  Actc1

  (MGI:87905)

• Mutation details: The heart restricted alpha-myosin heavy chain promoter drives the expression of human cardiac actin with the E99K mutation in codon 101. Two lines were established, however the pound symbol (#) is used because a line number is not specified. (J:175388)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:175388 Song W, et al., Molecular mechanism of the E99K mutation in cardiac actin (ACTC Gene) that causes apical hypertrophy in man and mouse. J Biol Chem. 2011 Aug 5;286(31):27582-93
• All: 5 reference(s)