Tg(Amh-SMAD2*)#Jebu
Transgene Detail

Summary

• Symbol: Tg(Amh-SMAD2*)#Jebu
• Name: transgene insertion, Joanna E Burdette
• MGI ID: MGI:5543909
• Synonyms: Smad2DN
• Transgene: Tg(Amh-SMAD2*)#Jebu Location: unknown
• Alliance: Tg(Amh-SMAD2*)#Jebu page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Dominant negative, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Amh-SMAD2*)#Jebu expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SMAD2 (4087)

  Smad2

  (MGI:108051)

  Expresses a C-terminal truncation of the human SMAD2 gene

• Mutation details: This transgene consists of a mouse minimal Mullerian-inhibiting substance promoter (-180 bp), an epitope Flag tag, a C-terminal truncation of the human Smad2 gene resulting in a dominant negative effect, and a human GH polyadenylation sequence. The Amh promoter drives transgene expression in testicular Sertoli cells and ovarian granulosa cells. (J:200783)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:200783 Quartuccio SM, et al., Conditional inactivation of p53 in mouse ovarian surface epithelium does not alter MIS driven Smad2-dominant negative epithelium-lined inclusion cysts or teratomas. PLoS One. 2013;8(5):e65067
• All: 1 reference(s)