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Tg(Thy1-VAPB*P56S,-EGFP)D3Cai
Transgene Detail
Summary
Symbol: Tg(Thy1-VAPB*P56S,-EGFP)D3Cai
Name: transgene insertion D3, Huaibin Cai
MGI ID: MGI:5544194
Synonyms: P56S VAPB Tg
Transgene: Tg(Thy1-VAPB*P56S,-EGFP)D3Cai  Location: unknown  
Alliance: Tg(Thy1-VAPB*P56S,-EGFP)D3Cai page
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Thy1-VAPB*P56S,-EGFP)D3Cai expresses 1 gene
 
Mutation detailsThe human VAPB cDNA with a substitution of proline with serine at residue 56 (P56S) is under the control of a pan-neuronal promoter Thy1.2. Three lines were generated. qRT-PCR indicated more than 20-fold overexpression of mRNA. Protein expression was detected in the cerebral cortex, spinal cord, striatum, and hippocampus. (J:202148)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
tg1  Disease Model
 
Phenotypes:
Affected Systems
show or hide all annotated terms Sex:
 
behavior/neurological
impaired coordination
short stride length
increased vertical activity
increased locomotor activity
growth/size/body
decreased body weight
nervous system
abnormal corticospinal tract morphology
abnormal neuron morphology
decreased motor neuron number
motor neuron degeneration
abnormal synaptic bouton morphology
abnormal nervous system physiology
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Key:
disease model   expected model not found
Models:
Human Diseases
tg1
IDs
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:202148 Aliaga L, et al., Amyotrophic lateral sclerosis-related VAPB P56S mutation differentially affects the function and survival of corticospinal and spinal motor neurons. Hum Mol Genet. 2013 Nov 1;22(21):4293-305
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory