Tg(Thy1-VAPB*P56S,-EGFP)D3Cai
Transgene Detail
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Symbol: |
Tg(Thy1-VAPB*P56S,-EGFP)D3Cai |
Name: |
transgene insertion D3, Huaibin Cai |
MGI ID: |
MGI:5544194 |
Synonyms: |
P56S VAPB Tg |
Transgene: |
Tg(Thy1-VAPB*P56S,-EGFP)D3Cai Location: unknown
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Alliance: |
Tg(Thy1-VAPB*P56S,-EGFP)D3Cai page
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Thy1-VAPB*P56S,-EGFP)D3Cai expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
VAPB (9217) |
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Mutation details: The human VAPB cDNA with a substitution of proline with serine at residue 56 (P56S) is under the control of a pan-neuronal promoter Thy1.2. Three lines were generated. qRT-PCR indicated more than 20-fold overexpression of mRNA. Protein expression was detected in the cerebral cortex, spinal cord, striatum, and hippocampus.
(J:202148)
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Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
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Phenotypes: |
Affected Systems |
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behavior/neurological
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impaired coordination
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short stride length
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increased vertical activity
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increased locomotor activity
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growth/size/body
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decreased body weight
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nervous system
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abnormal corticospinal tract morphology
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abnormal neuron morphology
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decreased motor neuron number
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motor neuron degeneration
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abnormal synaptic bouton morphology
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abnormal nervous system physiology
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View phenotypes and curated references for all genotypes (concatenated display).
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Key: |
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disease model |
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expected model not found |
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Models:
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Human Diseases |
IDs
amyotrophic lateral sclerosis type 8
Close
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:202148 Aliaga L, et al., Amyotrophic lateral sclerosis-related VAPB P56S mutation differentially affects the function and survival of corticospinal and spinal motor neurons. Hum Mol Genet. 2013 Nov 1;22(21):4293-305 |
All: |
1 reference(s) |
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