Tg(Prnp-APPSweArc)#Rmni
Transgene Detail

Summary

• Symbol: Tg(Prnp-APPSweArc)#Rmni
• Name: transgene insertion, Roger M Nitsch
• MGI ID: MGI:5553464
• Synonyms: arcABeta
• Transgene: Tg(Prnp-APPSweArc)#Rmni Location: unknown
• Alliance: Tg(Prnp-APPSweArc)#Rmni page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-APPSweArc)#Rmni expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

  The gene encodes for the Swedish and Arctic mutations.

• Mutation details: The human APP695 containing the Swedish K670N and M671L and Artic E693G mutations is under the control of the prion protein promoter. The pound symbol (#) is used because the line is not specified, although the line used has a 6-fold overexpression of APP compared to endogenous APP levels. (J:128080)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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tg1  Disease Model	Tg(Prnp-APPSweArc)#Rmni/0	involves: C57BL/6 * DBA/2

Phenotypes:

Affected Systems	tg1
show or hide all annotated terms
behavior/neurological	√
abnormal learning/memory/conditioning	√
impaired active avoidance behavior	√
abnormal spatial working memory	√
increased anxiety-related response	√
decreased locomotor activity	√
increased locomotor activity	√
decreased thermal nociceptive threshold	√
cardiovascular system	√
abnormal vasodilation	√
homeostasis/metabolism	√
amyloid beta deposits	√
cerebral amyloid angiopathy	√
abnormal nitric oxide homeostasis	√
muscle	√
abnormal vasodilation	√
nervous system	√
amyloid beta deposits	√
cerebral amyloid angiopathy	√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	tg1
Alzheimer's disease IDs Alzheimer's disease       DOID:10652 ICD10CM:G30 ICD9CM:331.0 KEGG:05010 MESH:D000544 NCI:C2866 UMLS_CUI:C0002395 Close	√
cerebral amyloid angiopathy IDs cerebral amyloid angiopathy       DOID:9246 MESH:D028243 ORDO:85458 UMLS_CUI:C0268393 UMLS_CUI:C1510489 UMLS_CUI:C1527338 UMLS_CUI:C1956349 Close	√

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:128080 Knobloch M, et al., Intracellular Abeta and cognitive deficits precede beta-amyloid deposition in transgenic arcAbeta mice. Neurobiol Aging. 2007 Sep;28(9):1297-306
• All: 12 reference(s)