Tg(Prnp-APPSweArc)#Rmni
Transgene Detail

Summary

• Symbol: Tg(Prnp-APPSweArc)#Rmni
• Name: transgene insertion, Roger M Nitsch
• MGI ID: MGI:5553464
• Synonyms: arcABeta
• Transgene: Tg(Prnp-APPSweArc)#Rmni Location: unknown
• Alliance: Tg(Prnp-APPSweArc)#Rmni page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-APPSweArc)#Rmni expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

  The gene encodes for the Swedish and Arctic mutations.

• Mutation details: The human APP695 containing the Swedish K670N and M671L and Artic E693G mutations is under the control of the prion protein promoter. The pound symbol (#) is used because the line is not specified, although the line used has a 6-fold overexpression of APP compared to endogenous APP levels. (J:128080)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:128080 Knobloch M, et al., Intracellular Abeta and cognitive deficits precede beta-amyloid deposition in transgenic arcAbeta mice. Neurobiol Aging. 2007 Sep;28(9):1297-306
• All: 11 reference(s)