Tg(Myh6-Gnaq*Q209L)52Ejne
Transgene Detail

Summary

• Symbol: Tg(Myh6-Gnaq*Q209L)52Ejne
• Name: transgene insertion 52, E J Neer
• MGI ID: MGI:5559165
• Synonyms: alphaQ*52
• Transgene: Tg(Myh6-Gnaq*Q209L)52Ejne Location: unknown
• Alliance: Tg(Myh6-Gnaq*Q209L)52Ejne page

Gross and microscopic pathology of hearts from Tg(Myh6-Gnaq*Q209L)52Ejne/? mice

Show the 1 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Gnaq*Q209L)52Ejne expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Gnaq (MGI:95776)	this mutation renders Gnaq constitutively active

• Mutation details: The murine 5.5-kb alpha-myosin heavy chain promoter drives the cardiac-specific expression of mouse hemagglutinin (HA) epitope-tagged constitutively active (Q209L mutation) G protein alpha q subunit. Two lines, 44 and 52, were made. (J:204274)

Schematic representation of the transgenic vector for Tg(Myh6-Gnaq*Q209L)52Ejne

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:204274 Mende U, et al., Transient cardiac expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways. Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13893-8
• All: 3 reference(s)