Tg(KRT14-HPV8)85Vuc
Transgene Detail

Summary

• Symbol: Tg(KRT14-HPV8)85Vuc
• Name: transgene insertion 85, Herbert Pfister
• MGI ID: MGI:5559369
• Transgene: Tg(KRT14-HPV8)85Vuc Location: unknown
• Alliance: Tg(KRT14-HPV8)85Vuc page

Transgene origin

• Strain of Origin: (DBA x C57BL/6)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene consists of the human keratin 14 promoter, intron 2 of the rabbit beta-globin gene, the complete early region and parts of the noncoding region and the L2-open reading frame of human papillomavirus type 8 (HPV8), and keratin 14 polyadenylation sequence. The keratin 14 promoter drives expression of the transgene in basal cells of the squamous epithelium. Three lines were generated: 9, 61, 85. Line 85 has 70 copies of the transgene. (J:96784)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:96784 Schaper ID, et al., Development of skin tumors in mice transgenic for early genes of human papillomavirus type 8. Cancer Res. 2005 Feb 15;65(4):1394-400
• All: 1 reference(s)