Tg(Thy1-APPSweAut)A7Tiwa
Transgene Detail

Summary

• Symbol: Tg(Thy1-APPSweAut)A7Tiwa
• Name: transgene insertion A7, Takeshi Iwatsubo
• MGI ID: MGI:5559448
• Synonyms: A7 APP Tg, Tg(Thy1-APP*K670N*M671L*T714I)A7Tiwa, Tg(Thy1-APP*Swe*Aut)A7Tiwa
• Transgene: Tg(Thy1-APPSweAut)A7Tiwa Location: unknown
• Alliance: Tg(Thy1-APPSweAut)A7Tiwa page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-APPSweAut)A7Tiwa expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

  The gene encodes for the Swedish and Austrian mutations.

• Mutation details: This transgene expresses the human APP695 harboring the Swedish K670N and M671L (Swe) and the Austrian T714I (Aut) familial Alzheimer disease mutations in neurons under the control of the Thy1.2 promoter. Immunoblotting shows that expression of transgenic human APP proteins is about 1.4 fold that of endogenous murine App. (J:204270)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:204270 Yamada K, et al., Abeta immunotherapy: intracerebral sequestration of Abeta by an anti-Abeta monoclonal antibody 266 with high affinity to soluble Abeta. J Neurosci. 2009 Sep 9;29(36):11393-8
• All: 7 reference(s)