Tg(PDGFB-LRRK2*G2019S)32Hlw
Transgene Detail

Summary

• Symbol: Tg(PDGFB-LRRK2*G2019S)32Hlw
• Name: transgene insertion 32, Hung-Li Wang
• MGI ID: MGI:5559903
• Synonyms: (G2019S) LRRK2
• Transgene: Tg(PDGFB-LRRK2*G2019S)32Hlw Location: unknown
• Alliance: Tg(PDGFB-LRRK2*G2019S)32Hlw page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(PDGFB-LRRK2*G2019S)32Hlw expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  LRRK2 (120892)

  Lrrk2

  (MGI:1913975)

• Mutation details: The human LRRK2 with the disease causing G2019S mutation with an HA tag on the C-terminus is under the control of the CMV enhancer and PDGF-beta chain promoter. Two lines were established, 32 and 51. This line contains 10 copies of the transgene. (J:204793)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:204793 Chen CY, et al., (G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD. Cell Death Differ. 2012 Oct;19(10):1623-33
• All: 3 reference(s)