Tg(KRT14-Il18)#Knak
Transgene Detail

Summary

• Symbol: Tg(KRT14-Il18)#Knak
• Name: transgene insertion, Kenji Nakanishi
• MGI ID: MGI:2388817
• Synonyms: KIL-18Tg
• Transgene: Tg(KRT14-Il18)#Knak Location: unknown
• Alliance: Tg(KRT14-Il18)#Knak page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(KRT14-Il18)#Knak expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Il18 (MGI:107936)

• Mutation details: The transgenic construct consisted of an Il18 cDNA fragment was adjoined to a human keratin 14 promoter region and rabbit beta-globin intron. The human keratin 14 promoter drives expression in epidermal tissue. Northern blot analysis of showed expression of the construct in the skin, but not in liver, kidney, colon, lung,brain, or spleen. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:78602)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:78602 Konishi H, et al., IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions. Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11340-5
• All: 3 reference(s)