Tg(KRT14-Il4)#Lsch
Transgene Detail

Summary

• Symbol: Tg(KRT14-Il4)#Lsch
• Name: transgene insertion, Lawrence S Chan
• MGI ID: MGI:5564943
• Synonyms: Il-4 Tg
• Transgene: Tg(KRT14-Il4)#Lsch Location: unknown
• Alliance: Tg(KRT14-Il4)#Lsch page

Transgene origin

• Strain of Origin: (BALB/cBy x C57BL/6)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(KRT14-Il4)#Lsch expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Il4 (MGI:96556)

• Mutation details: This transgene consists of the human basal keratinocyte (keratin 14) specific promoter/enhancer, rabbit beta-globin intron, murine Il4 cDNA, and KRT14 polyA tail. RT-PCR confirmed skin expression of the transgenic mRNA. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:126285)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:126285 Chan LS, et al., Expression of interleukin-4 in the epidermis of transgenic mice results in a pruritic inflammatory skin disease: an experimental animal model to study atopic dermatitis. J Invest Dermatol. 2001 Oct;117(4):977-83
• All: 11 reference(s)