Tg(Pbsn-MYC)#Tt
Transgene Detail

Summary

• Symbol: Tg(Pbsn-MYC)#Tt
• Name: transgene insertion, Timothy C Thompson
• MGI ID: MGI:5566832
• Synonyms: ARR(2)PB-c-myc
• Transgene: Tg(Pbsn-MYC)#Tt Location: unknown
• Alliance: Tg(Pbsn-MYC)#Tt page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Pbsn-MYC)#Tt expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MYC (4609)

  Bmyc	(MGI:88184)
  Myc	(MGI:97250)

• Mutation details: The full-length human MYC cDNA is under the control of a modified rat probasin promoter that has a sequence composed of 2 repeats of the androgen-responsive region inserted into it (ARR(2)PB). To maximize expression of the transgene, the rabbit beta-globin gene fragment, KCR, which comprises part of exon I, intron I, and exon II, and contains the requisite splice donors and acceptors was added. Western blotting confirmed protein expression in the prostate. Four lines were generated: 32T, 35T, 37T, and 39T. However, the pound symbol (#) is used when line is not specified and/or lines are pooled. (J:205395)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:205395 Yang G, et al., Caveolin-1 upregulation contributes to c-Myc-induced high-grade prostatic intraepithelial neoplasia and prostate cancer. Mol Cancer Res. 2012 Feb;10(2):218-29
• All: 1 reference(s)