Tg(CMV-HTT*48Q)BTag
Transgene Detail

Summary

• Symbol: Tg(CMV-HTT*48Q)BTag
• Name: transgene insertion B, Danilo A Tagle
• MGI ID: MGI:5569528
• Synonyms: HD48B
• Transgene: Tg(CMV-HTT*48Q)BTag Location: unknown
• Alliance: Tg(CMV-HTT*48Q)BTag page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CMV-HTT*48Q)BTag expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HTT (3064)

  Htt	(MGI:96067)

• Mutation details: The full-length human huntingtin cDNA containing 48 CAG repeats is under the control of the cytomegalovirus promoter and SV40 enhancer. Three lines, B-D, were established. No CAG repeat instability was detected by PCR amplification. Western blot analysis confirmed transgene expression in the brain, including primary and secondary motor cortices, entorhinal cortex, striatum, hippocampus and cerebellum. Transgene expression in the brain is five times that of endogenous levels. (J:50173)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:50173 Reddy PH, et al., Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA. Nat Genet. 1998 Oct;20(2):198-202
• All: 3 reference(s)