Tg(CMV-HTT*89Q)ATag
Transgene Detail

Summary

• Symbol: Tg(CMV-HTT*89Q)ATag
• Name: transgene insertion A, Danilo A Tagle
• MGI ID: MGI:5569532
• Synonyms: HD89A
• Transgene: Tg(CMV-HTT*89Q)ATag Location: unknown
• Alliance: Tg(CMV-HTT*89Q)ATag page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CMV-HTT*89Q)ATag expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HTT (3064)

  Htt	(MGI:96067)

• Mutation details: The full-length human huntingtin cDNA containing 89 CAG repeats is under the control of the cytomegalovirus promoter and SV40 enhancer. Three lines, A-C, were established. No CAG repeat instability was detected by PCR amplification. Western blot analysis confirmed transgene expression in the brain. Southern blot analysis indicates a copy number of six. (J:50173)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:50173 Reddy PH, et al., Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA. Nat Genet. 1998 Oct;20(2):198-202
• All: 3 reference(s)