Tg(tetO-MYCN,-luc)#Waw
Transgene Detail

Summary

• Symbol: Tg(tetO-MYCN,-luc)#Waw
• Name: transgene insertion, William A Weiss
• MGI ID: MGI:5570746
• Synonyms: TML, TRE-MYCN/Luc
• Transgene: Tg(tetO-MYCN,-luc)#Waw Location: unknown
• Alliance: Tg(tetO-MYCN,-luc)#Waw page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence, Reporter)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-MYCN,-luc)#Waw expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MYCN (4613)

  Mycn	(MGI:97357)
  Mycs	(MGI:1332242)

• Mutation details: The bi-directional tetracycline-responsive operator drives inducible expression of the human MYCN cDNA and firefly luciferase. In double transgenic mice also expressing the tetracycline transactivating or reverse transactivating element (tTA or rtTA), expression of MYCN can be regulated by doxycycline administration or removal. (J:160518)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:160518 Swartling FJ, et al., Pleiotropic role for MYCN in medulloblastoma. Genes Dev. 2010 May 15;24(10):1059-72
• All: 9 reference(s)