Tg(Cnp-SNCA)M2Vle
Transgene Detail

Summary

• Symbol: Tg(Cnp-SNCA)M2Vle
• Name: transgene insertion M2, Virginia M Y Lee
• MGI ID: MGI:5573154
• Synonyms: alphaSyn CNP Tg
• Transgene: Tg(Cnp-SNCA)M2Vle Location: unknown
• Alliance: Tg(Cnp-SNCA)M2Vle page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Cnp-SNCA)M2Vle expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SNCA (6622)

  Snca	(MGI:1277151)

• Mutation details: The murine 2', 3'-cyclic nucleotide 3'-phosphodiesterase promoter drives expression of human wild-type alpha-synuclein in oligodendrocytes. Immunohistochemistry confirmed expression in oligodendrocytes. (J:127923)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:127923 Giasson BI, et al., Initiation and synergistic fibrillization of tau and alpha-synuclein. Science. 2003 Apr 25;300(5619):636-40
• All: 5 reference(s)