Tg(Stat3*)9199Alau
Transgene Detail

Summary

• Symbol: Tg(Stat3*)9199Alau
• Name: transgene insertion 9199, Arian Laurence
• MGI ID: MGI:5574060
• Synonyms: mut-Stat3, Stat3-deltaV463, Tg(Stat3*)L1Alau
• Transgene: Tg(Stat3*)9199Alau Location: unknown
• Alliance: Tg(Stat3*)9199Alau page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Dominant negative, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Stat3*)9199Alau expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Stat3 (MGI:103038)

• Mutation details: This transgene consists of a bacterial artificial chromosome (RP24-236G5 BAC) containing mouse Stat3 that was modified to delete valine 463 from the binding domain. The deletion consists of a 1,163 bp DNA fragment starting with the last codon of Stat3 exon 15 and ending at the 5' end of exon 16. This mutation affects Stat3 DNA binding activity in a dominant negative way. Line 9199 (L1) contains 2 transgene copies. (J:210877)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:210877 Steward-Tharp SM, et al., A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3. Blood. 2014 May 8;123(19):2978-87
• All: 11 reference(s)