Tg(Tek-Nfkbia*S32A*S36A)1Gkl
Transgene Detail
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Symbol: |
Tg(Tek-Nfkbia*S32A*S36A)1Gkl |
Name: |
transgene insertion 1, George Kollias |
MGI ID: |
MGI:5575645 |
Synonyms: |
Tg(Tie2-IkB)1Gkl, Tie2DNIkappaBalpha, Tie2floxedstop-IkappaBalpha |
Transgene: |
Tg(Tek-Nfkbia*S32A*S36A)1Gkl Location: unknown
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Alliance: |
Tg(Tek-Nfkbia*S32A*S36A)1Gkl page
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Strain of Origin: |
C57BL/6 or CBA
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Transgene Type: |
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Transgenic (Conditional ready, Inserted expressed sequence) |
Mutation: |
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Insertion
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Mutation details: The 19 kb transgene construct contains the Tek (endothelial-specific receptor tyrosine kinase; formerly Tie2) promoter followed by a loxP-flanked Stop signal, a beta-globin intron and a cDNA encoding a hemagglutinin- (HA-) tagged NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha; also called IkappaBalpha) with alanine substituted for serine at amino acid positions 32 (S32A) and 36 (S36A). Upon cre recombinase expression, mice bearing this transgene express this superrepressor of NF-kappaB specifically in endothelial cells.
(J:82809)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:82809 European Mouse Mutant Archive, Information obtained from the European Mouse Mutant Archive (EMMA). Unpublished. 2003-2013; |
All: |
1 reference(s) |
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