Tg(Thy1-FUS*)19Vlb
Transgene Detail

Summary

• Symbol: Tg(Thy1-FUS*)19Vlb
• Name: transgene insertion 19, Vladimir L Buchman
• MGI ID: MGI:5577178
• Synonyms: FUS-TG
• Transgene: Tg(Thy1-FUS*)19Vlb Location: unknown
• Alliance: Tg(Thy1-FUS*)19Vlb page

Transgene origin

• Strain of Origin: C57BL/6 x CBA

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene consists of a fragment of human FUS 1-359 cDNA including 9 bp of 5'-UTR under the control of the Thy1 promoter. This FUS variant is predominantly cytoplasmic as it lacks the nuclear localization signal, highly aggregate-prone, and lacks a region responsible for RNA recognition and binding. Western blot confirmed expression in neural tissues. (J:203550)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:203550 Shelkovnikova TA, et al., Fused in sarcoma (FUS) protein lacking nuclear localization signal (NLS) and major RNA binding motifs triggers proteinopathy and severe motor phenotype in transgenic mice. J Biol Chem. 2013 Aug 30;288(35):25266-74
• All: 5 reference(s)