Tg(TG-TPR/NTRK1)5215Rstn
Transgene Detail

Summary

• Symbol: Tg(TG-TPR/NTRK1)5215Rstn
• Name: transgene insertion 5215, Jay Rothstein
• MGI ID: MGI:5569747
• Synonyms: TRK-T1, TRK-T1 line 5215
• Transgene: Tg(TG-TPR/NTRK1)5215Rstn Location: unknown
• Alliance: Tg(TG-TPR/NTRK1)5215Rstn page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene contained the bovine thyroglobulin (TG) promoter and a translocation fusion product of human TPR and human NTRK1, something observed in human papillary thyroid carcinomas. Transgene expression and thyroid-specific expression was verified by RNase protection analysis. Line 5215 was one of three lines established. (J:67120)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(TG-TPR/NTRK1)5215Rstn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Three lines were generated: 5215, 5218, and 5221.

References

• Original: J:67120 Russell JP, et al., The TRK-T1 fusion protein induces neoplastic transformation of thyroid epithelium. Oncogene. 2000 Nov 23;19(50):5729-35
• All: 1 reference(s)