Tg(IVL-KLK5)#Hov
Transgene Detail

Summary

• Symbol: Tg(IVL-KLK5)#Hov
• Name: transgene insertion, Alain Hovnanian
• MGI ID: MGI:5583016
• Synonyms: Tg-KLK5
• Transgene: Tg(IVL-KLK5)#Hov Location: unknown
• Alliance: Tg(IVL-KLK5)#Hov page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(IVL-KLK5)#Hov expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  KLK5 (25818)

  Klk5	(MGI:1915918)

• Mutation details: The human involucrin promoter (promoter, exon 1 and intron1) drives the expression of the human KLK5 cDNA fused to the FLAG tag in the granular layer of the epidermis. Western blot confirmed expression in epidermal extracts and immunostaining confirmed protein expression in the upper epidermis. The pound symbol (#) is used when line is not specified. (J:210758)

Disease models

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:210758 Furio L, et al., Transgenic kallikrein 5 mice reproduce major cutaneous and systemic hallmarks of Netherton syndrome. J Exp Med. 2014 Mar 10;211(3):499-513
• All: 2 reference(s)