Del(17Trem1-Trem3)1Jkt Cytogenetic Marker Detail

Summary

• Symbol
  Del(17Trem1-Trem3)1Jkt
• Name
  deletion, Chr 17, Julia Klesney-Tait 1

• Feature Type
  chromosomal deletion
• IDs
  MGI:5584293

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 17, Syntenic

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  18 phenotypes from 1 allele in 1 genetic background
  1 images
  7 phenotype references
  

• All Mutations and Alleles
  1
• Targeted
  1
• Find Mice (IMSR)
  0 strains or lines available

Mice homozygous for a knock-out allele of Trem1 and Trem3 exhibit increased susceptibility to P. aeruginosa infection with reduced neutrophil transepithelial migration.

References

• Summaries
  All 7

  Phenotypes 7
• Earliest
  J:194295 Klesney-Tait J, et al., Transepithelial migration of neutrophils into the lung requires TREM-1. J Clin Invest. 2013 Jan 2;123(1):138-49
• Latest
  J:344857 McQueen BE, et al., Reduced Uterine Tissue Damage during Chlamydia muridarum Infection in TREM-1,3-Deficient Mice. Infect Immun. 2021 Sep 16;89(10):e0007221