Del(11Stat5a-Stat5b)1Mam Cytogenetic Marker Detail

Summary

• Symbol
  Del(11Stat5a-Stat5b)1Mam
• Name
  deletion, chr 11, Lothar Hennighausen 1

• Feature Type
  chromosomal deletion
• IDs
  MGI:5587830

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 11, Syntenic

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  18 phenotypes from 1 allele in 3 genetic backgrounds
  1 phenotype from multigenic genotypes
  34 phenotype references
  

• All Mutations and Alleles
  1
• Targeted
  1
• Find Mice (IMSR)
  0 strains or lines available

Mice homozygous for this deletion exhibit perinatally lethality and premature death with B and T cell immune defects.

References

• Summaries
  All 35

  Phenotypes 34
• Earliest
  J:92770 Cui Y, et al., Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation. Mol Cell Biol. 2004 Sep;24(18):8037-47
• Latest
  J:317684 Hidalgo D, et al., EpoR stimulates rapid cycling and larger red cells during mouse and human erythropoiesis. Nat Commun. 2021 Dec 17;12(1):7334