Rr32 Other Genome Feature Detail

Summary

• Symbol
  Rr32
• Name
  regulatory region 32
• Synonyms
  Ifng CNS-22

• Feature Type
  enhancer
• IDs
  MGI:5588377

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 10, Syntenic

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotypes from 1 allele in 1 genetic background
  1 phenotype reference
  

• All Mutations and Alleles
  1
• Targeted
  1
• Find Mice (IMSR)
  0 strains or lines available

Mice homozygous for a knock-out allele exhibit impaired Ifng expression due to disrupted locus-wide histone acetylation.

References

• Summaries
  All 3

  Phenotypes 1
• Earliest
  J:116207 Hatton RD, et al., A distal conserved sequence element controls Ifng gene expression by T cells and NK cells. Immunity. 2006 Nov;25(5):717-29
• Latest
  J:208819 Balasubramani A, et al., Deletion of a conserved cis-element in the Ifng locus highlights the role of acute histone acetylation in modulating inducible gene transcription. PLoS Genet. 2014 Jan;10(1):e1003969