Tg(tetO-Fgfr3*R248C/Fgfr1)#Dor
Transgene Detail

Summary

• Symbol: Tg(tetO-Fgfr3*R248C/Fgfr1)#Dor
• Name: transgene insertion, David M Ornitz
• MGI ID: MGI:5604241
• Synonyms: TRE-caFgfr1, TRE-caFgfr1-myc, TRE-Fgfr31c(R248C)-c-myc
• Transgene: Tg(tetO-Fgfr3*R248C/Fgfr1)#Dor Location: unknown
• Alliance: Tg(tetO-Fgfr3*R248C/Fgfr1)#Dor page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene consists of the tetracycline response element, a chimeric receptor consisting of the Fgfr3 extracellular and transmembrane domains with the R248C mutation fused to the Fgfr1 tyrosine kinase domain and a c-myc tag. The R248C mutation in Fgfr3 confers ligand-independent constitutive activity. By fusing this mutant Fgfr3 receptor to the Fgfr1 tyrosine kinase domain, a receptor that constitutively activates Fgfr1 signaling in the absence of ligand is produced. Four lines were produced however the pound symbol (#) is used because the line is not specified. (J:211151)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:211151 Cilvik SN, et al., Fibroblast growth factor receptor 1 signaling in adult cardiomyocytes increases contractility and results in a hypertrophic cardiomyopathy. PLoS One. 2013;8(12):e82979
• All: 4 reference(s)