Tg(MMTV-Erbb2)12Pjo
Transgene Detail

Summary

• Symbol: Tg(MMTV-Erbb2)12Pjo
• Name: transgene insertion 12, Paul Jolicoeur
• MGI ID: MGI:3047089
• Synonyms: MN-12
• Transgene: Tg(MMTV-Erbb2)12Pjo Location: unknown
• Alliance: Tg(MMTV-Erbb2)12Pjo page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(MMTV-Erbb2)12Pjo expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Erbb2 (24337)

  Erbb2

  (MGI:95410)

• Mutation details: This transgene contains the mouse mammary tumor virus (MMTV) promoter and an activated form of the rat avian erythroblastosis B2 oncogene (Erbb2), which carries a Val664Glu mutation. Note: the Erbb2 gene was previously called neu. (J:72129)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(MMTV-Erbb2)12Pjo

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:72129 Bouchard L, et al., Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c-neu oncogene. Cell. 1989 Jun 16;57(6):931-6
• All: 1 reference(s)