Naipc Complex/Cluster/Region Detail

Summary

• Symbol
  Naipc
• Name
  NLR family, apoptosis inhibitory protein cluster

• Feature Type
  complex/cluster/region
• IDs
  MGI:5614493
• Cluster Members
  Naip2, Naip1-rs1, Naip5 ... (11 members)

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 13, Syntenic

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  6 phenotypes from 2 alleles in 3 genetic backgrounds
  1 phenotype reference
  

• All Mutations and Alleles
  2
• Targeted
  2
• Find Mice (IMSR)
  0 strains or lines available

Mice homozygous for a knock-out allele exhibit increased incidence of AOM- and DSS-induced tumors and decreased incidence of DSS-induced colitis.

References

• Summaries
  All 2

  Phenotypes 1
• Earliest
  J:222114 Allam R, et al., Epithelial NAIPs protect against colonic tumorigenesis. J Exp Med. 2015 Mar 9;212(3):369-83

Naipc Cluster contains:

More Data for these features

Member	Feature Type	Location
Naip2, NLR family, apoptosis inhibitory protein 2	protein coding gene	Chr13:100280571-100338600 (-)
Naip1-rs1, NLR family, apoptosis inhibitory protein 1, related sequence 1	pseudogene	Chr13:100325401-100325663 (-)
Naip5, NLR family, apoptosis inhibitory protein 5	protein coding gene	Chr13:100348247-100382831 (-)
Naip4, NLR family, apoptosis inhibitory protein 4	protein coding gene	Chr13:100382985-100452816
Naip3-ps1, NLR family, apoptosis inhibitory protein 3, pseudogene 1	pseudogene	Chr13:100401253-100415325 (-)
Naip3-ps3, NLR family, apoptosis inhibitory protein 3, pseudogene 3	pseudogene	Chr13:100411706-100412442
Naip3-ps2, NLR family, apoptosis inhibitory protein 3, pseudogene 2	pseudogene	Chr13:100417523-100418347
Naip6, NLR family, apoptosis inhibitory protein 6	protein coding gene	Chr13:100417629-100453124 (-)
Naip3, NLR family, apoptosis inhibitory protein 3	pseudogene	Chr13:100476652-100515468 (-)
Naip1, NLR family, apoptosis inhibitory protein 1	protein coding gene	Chr13:100544272-100589372 (-)
Naip7, NLR family, apoptosis inhibitory protein 7	protein coding gene	Chr13, Syntenic