Tg(SOD1*)D-14Dbo
Transgene Detail

Summary

• Symbol: Tg(SOD1*)D-14Dbo
• Name: transgene insertion D-14, David R Borchelt
• MGI ID: MGI:5621172
• Synonyms: Cu-V103Z
• Transgene: Tg(SOD1*)D-14Dbo Location: unknown
• Alliance: Tg(SOD1*)D-14Dbo page

Transgene origin

• Strain of Origin: (C3H/HeJ x C57BL/6J)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene contains a variant of human SOD1 that encodes a termination at codon position 103 (V103Z) with mutations at histidines at positions 46, 48, and 63 to R, Q, and G, respectively, to eliminate copper binding. In addition introns between exons 3, 4, and 5 of SOD1 were removed, creating a fragment with just two introns (one between exon 1 and 2 and one between exon 2 and 3) and exons 3, 4, and 5 fused to make one new exon. Two lines, E-17 and D-14, were established. (J:218091)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:218091 Xu G, et al., Direct and indirect mechanisms for wild-type SOD1 to enhance the toxicity of mutant SOD1 in bigenic transgenic mice. Hum Mol Genet. 2015 Feb 15;24(4):1019-35
• All: 3 reference(s)