Tg(SOD1*G85R/EYFP)737Alho
Transgene Detail
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Symbol: |
Tg(SOD1*G85R/EYFP)737Alho |
Name: |
transgene insertion 737, Arthur L Horwich |
MGI ID: |
MGI:5630056 |
Synonyms: |
G85R SOD1-YFP |
Transgene: |
Tg(SOD1*G85R/EYFP)737Alho Location: unknown
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Alliance: |
Tg(SOD1*G85R/EYFP)737Alho page
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Strain of Origin: |
(C57BL/6J x SJL/J)F2
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence, Reporter) |
Mutation: |
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Insertion
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Tg(SOD1*G85R/EYFP)737Alho expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
SOD1 (6647) |
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Mutation details: A 12 kb genomic fragment of human SOD carrying the glycine to arginine substitution at amino acid 85 (G85R) fused to EYFP coding sequence through its C-terminal coding sequence in exon 5 was used as the transgene. The G85R mutation results in a misfolded protein associated with amyotrophic lateral sclerosis in humans and the mutant fusion protein behaves as a misfolded monomer. Southern blot analysis indicates that line 737 carries multiple transgene insertions.
(J:144475)
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Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
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Loading... | | | involves: C57BL/6J * SJL/J | |
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Phenotypes: |
Affected Systems |
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behavior/neurological
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paralysis
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cellular
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abnormal autophagy
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homeostasis/metabolism
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abnormal autophagy
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nervous system
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abnormal motor neuron morphology
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abnormal spinal cord ventral horn morphology
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abnormal nervous system physiology
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View phenotypes and curated references for all genotypes (concatenated display).
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Key: |
√ |
disease model |
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expected model not found |
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Models:
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Human Diseases |
IDs
amyotrophic lateral sclerosis type 1
Close
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:144475 Wang J, et al., Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS. Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1392-7 |
All: |
7 reference(s) |
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