Tg(Mbp-SNCA)29Ema
Transgene Detail

Summary

• Symbol: Tg(Mbp-SNCA)29Ema
• Name: transgene insertion 29, Eliezer Masliah
• MGI ID: MGI:5634090
• Synonyms: MBP halpha-syn tg
• Transgene: Tg(Mbp-SNCA)29Ema Location: unknown
• Alliance: Tg(Mbp-SNCA)29Ema page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Mbp-SNCA)29Ema expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SNCA (6622)

  Snca	(MGI:1277151)

• Mutation details: The murine Mbp promoter drives the expression of human alpha-synuclein cDNA (nucleotides 53-475). Line 29 is the highest expressor, followed by lines 1, 2, and 31. Highest mRNA expression is seen in the corpus callosum, followed by white matter tracts in the brainstem, spinal cord, basal ganglia, and cerebellum and lowest levels in the hippocampus, neocortex, and cortical layers in the cerebellum. Immunohistochemical analysis indicates protein expression in glial but not neuroal cells of the neocortex, basal ganglia, corpus callosum and cerebellum. Four lines were generated; 1, 2, 29, and 31. (J:102867)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:102867 Shults CW, et al., Neurological and neurodegenerative alterations in a transgenic mouse model expressing human alpha-synuclein under oligodendrocyte promoter: implications for multiple system atrophy. J Neurosci. 2005 Nov 16;25(46):10689-99
• All: 7 reference(s)