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Tg(CAG-Mtor*)#Atai
Transgene Detail
Summary
Symbol: Tg(CAG-Mtor*)#Atai
Name: transgene insertion, Atsu Aiba
MGI ID: MGI:5634713
Synonyms: CAG-mTORSL1+IT
Transgene: Tg(CAG-Mtor*)#Atai  Location: unknown  
Alliance: Tg(CAG-Mtor*)#Atai page
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Constitutively active, Inducible, Inserted expressed sequence)
Inducer:    rapamycin
Mutation:    Insertion
 
Tg(CAG-Mtor*)#Atai expresses 1 gene
 
Mutation detailsThis transgene consists of the ubiquitous CAG promoter, a floxed neo cassette, and the mutant rat Mtor kinase, which harbors four point mutations in the FKBP12-rapamycin binding and kinase domains (V2198A, L2216H, L2260P, and I2017T) with a FLAG tag at the N terminus. Excision of the floxed neo gene by cre recombinase induces active Mtor expression. The pound symbol (#) is used when a line is not specified and/or lines are pooled. (J:211789)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
cn1  Disease Model
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * ICR
 
Phenotypes:
Affected Systems
show or hide all annotated terms
 
cellular
increased neuron apoptosis
nervous system
increased neuron apoptosis
small hippocampus
abnormal cerebral cortex morphology
decreased neuronal precursor cell number
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Key:
disease model   expected model not found
Models:
Human Diseases
cn1
IDs
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:211789 Kassai H, et al., Selective activation of mTORC1 signaling recapitulates microcephaly, tuberous sclerosis, and neurodegenerative diseases. Cell Rep. 2014 Jun 12;7(5):1626-39
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory