Tg(CAG-Mtor*)#Atai
Transgene Detail

Summary

• Symbol: Tg(CAG-Mtor*)#Atai
• Name: transgene insertion, Atsu Aiba
• MGI ID: MGI:5634713
• Synonyms: CAG-mTOR^SL1+IT
• Transgene: Tg(CAG-Mtor*)#Atai Location: unknown
• Alliance: Tg(CAG-Mtor*)#Atai page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Constitutively active, Inducible, Inserted expressed sequence)
• Inducer: rapamycin
• Mutation: Insertion
• Tg(CAG-Mtor*)#Atai expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Mtor (56718)

  Mtor	(MGI:1928394)

• Mutation details: This transgene consists of the ubiquitous CAG promoter, a floxed neo cassette, and the mutant rat Mtor kinase, which harbors four point mutations in the FKBP12-rapamycin binding and kinase domains (V2198A, L2216H, L2260P, and I2017T) with a FLAG tag at the N terminus. Excision of the floxed neo gene by cre recombinase induces active Mtor expression. The pound symbol (#) is used when a line is not specified and/or lines are pooled. (J:211789)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cn1  Disease Model	Emx1^tm1(cre)Ito/Emx1^+ Tg(CAG-Mtor*)#Atai/0	involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * ICR

Phenotypes:

Affected Systems	cn1
show or hide all annotated terms
cellular	√
increased neuron apoptosis	√
nervous system	√
increased neuron apoptosis	√
small hippocampus	√
abnormal cerebral cortex morphology	√
decreased neuronal precursor cell number	√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	cn1
tuberous sclerosis IDs tuberous sclerosis       DOID:13515 ICD10CM:Q85.1 ICD9CM:759.5 MESH:D014402 NCI:C3424 OMIM:PS191100 UMLS_CUI:C0041341 Close	√

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:211789 Kassai H, et al., Selective activation of mTORC1 signaling recapitulates microcephaly, tuberous sclerosis, and neurodegenerative diseases. Cell Rep. 2014 Jun 12;7(5):1626-39
• All: 3 reference(s)