Tg(CAG-Mtor*)#Atai
Transgene Detail
|
Symbol: |
Tg(CAG-Mtor*)#Atai |
Name: |
transgene insertion, Atsu Aiba |
MGI ID: |
MGI:5634713 |
Synonyms: |
CAG-mTORSL1+IT |
Transgene: |
Tg(CAG-Mtor*)#Atai Location: unknown
|
Alliance: |
Tg(CAG-Mtor*)#Atai page
|
|
|
Transgene Type: |
|
Transgenic (Constitutively active, Inducible, Inserted expressed sequence) |
Inducer: |
|
rapamycin |
Mutation: |
|
Insertion
|
|
|
Tg(CAG-Mtor*)#Atai expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
rat |
Mtor (56718) |
|
|
|
|
|
Mutation details: This transgene consists of the ubiquitous CAG promoter, a floxed neo cassette, and the mutant rat Mtor kinase, which harbors four point mutations in the FKBP12-rapamycin binding and kinase domains (V2198A, L2216H, L2260P, and I2017T) with a FLAG tag at the N terminus. Excision of the floxed neo gene by cre recombinase induces active Mtor expression. The pound symbol (#) is used when a line is not specified and/or lines are pooled.
(J:211789)
|
|
|
Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
|
Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
---|
Loading... | | | involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * ICR | |
|
Phenotypes: |
Affected Systems |
|
|
cellular
|
√
|
increased neuron apoptosis
|
√
|
nervous system
|
√
|
increased neuron apoptosis
|
√
|
small hippocampus
|
√
|
abnormal cerebral cortex morphology
|
√
|
decreased neuronal precursor cell number
|
√
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
Key: |
√ |
disease model |
|
 |
expected model not found |
|
Models:
|
|
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
|
Original: |
J:211789 Kassai H, et al., Selective activation of mTORC1 signaling recapitulates microcephaly, tuberous sclerosis, and neurodegenerative diseases. Cell Rep. 2014 Jun 12;7(5):1626-39 |
All: |
3 reference(s) |
|