Tg(Ly6a-GCSAM)102AIsg
Transgene Detail

Summary

• Symbol: Tg(Ly6a-GCSAM)102AIsg
• Name: transgene insertion 102A, Isidro Sanchez-Garcia
• MGI ID: MGI:5642051
• Synonyms: Sca1-HGAL
• Transgene: Tg(Ly6a-GCSAM)102AIsg Location: unknown
• Alliance: Tg(Ly6a-GCSAM)102AIsg page

Transgene origin

• Strain of Origin: CBA x C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ly6a-GCSAM)102AIsg expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  GCSAM (257144)

  Gcsam

  (MGI:102969)

• Mutation details: The human GCSAM cDNA with a V5 tag is under the control of the mouse Ly6a (Ly-6E.1) promoter to drive expression in Sca1+ hematopoietic stem/progenitor cells and Sca1+ fraction of mature B cells. Two lines were established, 102A and 102B, with no differences in the two lines. Line 102A is entered as a representative line. (J:221238)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:221238 Romero-Camarero I, et al., Germinal centre protein HGAL promotes lymphoid hyperplasia and amyloidosis via BCR-mediated Syk activation. Nat Commun. 2013;4:1338
• All: 1 reference(s)