Tg(Prnp-lacZ/ATXN10*)#Teas
Transgene Detail

Summary

• Symbol: Tg(Prnp-lacZ/ATXN10*)#Teas
• Name: transgene insertion, Tetsuo Ashizawa
• MGI ID: MGI:5644279
• Transgene: Tg(Prnp-lacZ/ATXN10*)#Teas Location: unknown
• Alliance: Tg(Prnp-lacZ/ATXN10*)#Teas page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(Prnp-lacZ/ATXN10*)#Teas expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ATXN10 (25814)

  Atxn10

  (MGI:1859293)

  Expression of 500 ATTCT repeats found in patients with Spinocerebellar Ataxia 10.

• Mutation details: This transgene consists of the rat prion promoter, lacZ reporter gene, and 500 ATTCT repeats of human ATXN10 (isolated from a Mexican patient with ataxia and epilepsy) inserted in the 3' UTR of lacZ. RT-PCR analysis shows that the transgene is widely expressed in the central nervous system, with highest expression in the hippocampus, and also in the heart, liver, muscle, and skin. Three founders (1,2, 3) were established, however the pound symbol (#) is used when line is not specified and/or lines are pooled. (J:222081)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:222081 White M, et al., Transgenic mice with SCA10 pentanucleotide repeats show motor phenotype and susceptibility to seizure: a toxic RNA gain-of-function model. J Neurosci Res. 2012 Mar;90(3):706-14
• All: 2 reference(s)