Tg(SFTPC-Tnf)2Pva
Transgene Detail

Summary

• Symbol: Tg(SFTPC-Tnf)2Pva
• Name: transgene insertion 2, Pierre Vassalli
• MGI ID: MGI:5644302
• Synonyms: SPC/TNF-alpha-UT
• Transgene: Tg(SFTPC-Tnf)2Pva Location: unknown
• Alliance: Tg(SFTPC-Tnf)2Pva page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(SFTPC-Tnf)2Pva expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tnf (MGI:104798)

• Mutation details: The human SFTPC promoter drives the expression of the full-length mouse Tnf, including the entire 3' UTR. Two lines, 2 and 10, were established. Line 2 with about 10 copies of the transgene was chosen as a representative line. Northern blots confirmed RNA expression in the lungs but not in other tissues (liver, spleen, heart, kidney, uterus, brain, large bowel, lymph nodes). (J:28120)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:28120 Miyazaki Y, et al., Expression of a tumor necrosis factor-alpha transgene in murine lung causes lymphocytic and fibrosing alveolitis. A mouse model of progressive pulmonary fibrosis. J Clin Invest. 1995 Jul;96(1):250-9
• All: 4 reference(s)