Tg(H2-K^b-Tcra,-Tcrb)1640Kurs
Transgene Detail

Summary

• Symbol: Tg(H2-K^b-Tcra,-Tcrb)1640Kurs
• Name: transgene insertion 1640, Florian C Kurschus
• MGI ID: MGI:5644514
• Synonyms: RR mouse, TCR¹⁶⁴⁰
• Transgene: Tg(H2-K^b-Tcra,-Tcrb)1640Kurs Location: unknown
• Alliance: Tg(H2-K^b-Tcra,-Tcrb)1640Kurs page

Severe infiltration, demyelination, and axonal damage in Tg(H2-K^b-Tcra,-Tcrb)1640Kurs/0 cerebellum and spinal cord

Show the 2 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(H2-K^b-Tcra,-Tcrb)1640Kurs expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcra (MGI:98553)
  mouse	Tcrb (MGI:98578)

• Mutation details: This transgene consists of a T-cell antigen receptor (TCR) that recognizes rat/mouse MOG peptide 92-106 bound to I-A^S under the control of the MHC class I H2-K^b promoter. The TCR uses Valpha8.3 and Vbeta4 genes derived from a MOG-specific encephalitogenic Th1-CD4+ T cell clone isolated from a wild-type SJL/J mouse immunized against recombinant rat Mog. Three founder lines were established, differing in distinct proportions of transgenic Valpha8.3+/Vbeta4+ CD4+ T cells in central and peripheral immune repertoires. In the high frequency line 1640, 99% of single-positive CD4+CD8- thymocytes express the transgenic TCR. (J:149511)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:149511 Pollinger B, et al., Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells. J Exp Med. 2009 Jun 8;206(6):1303-16
• All: 7 reference(s)