Tg(Myh6-Htr2b)1Lum
Transgene Detail

Summary

• Symbol: Tg(Myh6-Htr2b)1Lum
• Name: transgene insertion 1, Luc Maroteaux
• MGI ID: MGI:5645783
• Transgene: Tg(Myh6-Htr2b)1Lum Location: unknown
• Alliance: Tg(Myh6-Htr2b)1Lum page

Transgene origin

• Strain of Origin: CD-1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Htr2b)1Lum expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Htr2b (MGI:109323)

• Mutation details: The mouse alpha-myosin heavy chain (MHC) promoter drives the expression of mouse Htr2b cDNA in the heart. Immunoblot analysis showed that the HTR2B protein level was increased in heart lysate of transgenic compared with nontransgenic (NTG) mice. (J:128784)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:128784 Nebigil CG, et al., Overexpression of the serotonin 5-HT2B receptor in heart leads to abnormal mitochondrial function and cardiac hypertrophy. Circulation. 2003 Jul 1;107(25):3223-9
• All: 1 reference(s)