Tg(Igf2/LacZ,H19)YZ8Aco
Transgene Detail

Summary

• Symbol: Tg(Igf2/LacZ,H19)YZ8Aco
• Name: transgene insertion YZ8, Justin Ainscough
• MGI ID: MGI:5648557
• Transgene: Tg(Igf2/LacZ,H19)YZ8Aco Location: unknown
• Alliance: Tg(Igf2/LacZ,H19)YZ8Aco page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(Igf2/LacZ,H19)YZ8Aco expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	H19 (MGI:95891)
  mouse	Igf2 (MGI:96434)

• Mutation details: The 130 kb YAC transgene, YZ, contains the Igf2 and H19 genomic regions and in which the Igf2 coding sequence was interrupted with the lacZ reporter gene. The YZ YAC extends from promoter 1 of Igf2 to 35 kb downstream of H19, and includes the differentially methylated region around exons 5 to 6 of Igf2, the unmethylated intergenic hypersensitive region, A6-A4, the differentially methylated regions around H19 and the endoderm-specific enhancers downstream of H19. LacZ activity shows spatial expression of Igf2 in a subset of tissues. The imprinted H19 gene is only expressed when transmitted through the maternal germline. After paternal transmission the gene is repressed. Line YZ8 carries a single copy of the transgene. (J:43322)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:61351 Ainscough JF, et al., Appropriate expression of the mouse H19 gene utilises three or more distinct enhancer regions spread over more than 130 kb. Mech Dev. 2000 Mar 1;91(1-2):365-8
• All: 4 reference(s)