Tg(Alb-HRAS*G12V)28Yu
Transgene Detail

Summary

• Symbol: Tg(Alb-HRAS*G12V)28Yu
• Name: transgene insertion 28, Dae-Yeul Yu
• MGI ID: MGI:5661920
• Synonyms: H-ras12V Tg, Ras-Tg
• Transgene: Tg(Alb-HRAS*G12V)28Yu Location: unknown
• Alliance: Tg(Alb-HRAS*G12V)28Yu page

Transgene origin

• Strain of Origin: C57BL/6J x CBA/J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Alb-HRAS*G12V)28Yu expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HRAS (3265)

  Hras	(MGI:96224)

  The human sequence is modified to contain the amino acid substitution Gly12Val.

• Mutation details: The mouse promoter/enhancer drives liver-specific expression of the human cDNA with the mutation that results in the amino acid substitution of valine for glycine at position 12 (G12V). Lines 28 and 76 were generated with 1 and 4 to 16 copied of the transgene, respectively. (J:107083)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:107083 Wang AG, et al., Gender-dependent hepatic alterations in H-ras12V transgenic mice. J Hepatol. 2005 Nov;43(5):836-44
• All: 13 reference(s)