Tg(tetO-SPTBN2*)#Lpwr
Transgene Detail

Summary

• Symbol: Tg(tetO-SPTBN2*)#Lpwr
• Name: transgene insertion, Laura PW Ranum
• MGI ID: MGI:5662095
• Synonyms: TRE-SPdelta39
• Transgene: Tg(tetO-SPTBN2*)#Lpwr Location: unknown
• Alliance: Tg(tetO-SPTBN2*)#Lpwr page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-SPTBN2*)#Lpwr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SPTBN2 (6712)

  Sptbn2

  (MGI:1313261)

  The human sequence is modified to result in a 39 bp in-frame deletion.

• Mutation details: This transgene consists of the tetracycline-response element (TRE), minimal CMV promoter, and human SPTBN2 cDNA containing the American SCA5 mutation (1592_1630del) which results in a 39 bp in-frame deletion. (J:215593)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:215593 Armbrust KR, et al., Mutant beta-III spectrin causes mGluR1alpha mislocalization and functional deficits in a mouse model of spinocerebellar ataxia type 5. J Neurosci. 2014 Jul 23;34(30):9891-904
• All: 1 reference(s)