Tg(Cyp17a1-NGF)2456Oje
Transgene Detail

Summary

• Symbol: Tg(Cyp17a1-NGF)2456Oje
• Name: transgene insertion 2456, Sergio R Ojeda
• MGI ID: MGI:5662266
• Synonyms: 17NF
• Transgene: Tg(Cyp17a1-NGF)2456Oje Location: unknown
• Alliance: Tg(Cyp17a1-NGF)2456Oje page

Transgene origin

• Strain of Origin: (C57BL/6J x DBA/2J)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Cyp17a1-NGF)2456Oje expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  NGF (4803)

  Ngf	(MGI:97321)

• Mutation details: The human NGF gene is targeted to thecal-interstitial cells by the mouse 17alpha-hydroxylase promoter. RNase protection assays confirmed ovarian mRNA expression and to a much lesser extent, expression in the adrenal gland, in the kidney and the liver.Two lines, 2380 and 2456, were generated and exhibited similar phenotypes. Line 2456 was studied further. (J:158186)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:158186 Dissen GA, et al., Excessive ovarian production of nerve growth factor facilitates development of cystic ovarian morphology in mice and is a feature of polycystic ovarian syndrome in humans. Endocrinology. 2009 Jun;150(6):2906-14
• All: 4 reference(s)