Tg(Ckm-Chrnd*S262T)40Cgz
Transgene Detail

Summary

• Symbol: Tg(Ckm-Chrnd*S262T)40Cgz
• Name: transgene insertion 40, Christopher Gomez
• MGI ID: MGI:5694343
• Synonyms: deltaS6'T
• Transgene: Tg(Ckm-Chrnd*S262T)40Cgz Location: unknown
• Alliance: Tg(Ckm-Chrnd*S262T)40Cgz page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ckm-Chrnd*S262T)40Cgz expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Chrnd (MGI:87893)

• Mutation details: The murine mutant delta subunit of the acetylcholine receptor which has a threonine for serine substitution at position 262 (S262T) of the second transmembrane domain is under the control of the mouse creatine kinase muscle promoter. A neomycin resistance gene was also inserted downstream of the Chrnd cDNA. Four lines were established: 18, 22, 31, and 40. Line 40 has a transgene copy number of about 25 and is the medium expressing line. (J:31221)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:31221 Gomez CM, et al., A transgenic mouse model of the slow-channel syndrome. Muscle Nerve. 1996 Jan;19(1):79-87
• All: 2 reference(s)