Tg(Cd74-Nlrc4*)1Kyas
Transgene Detail

Summary

• Symbol: Tg(Cd74-Nlrc4*)1Kyas
• Name: transgene insertion 1, Koji Yasutomo
• MGI ID: MGI:5696384
• Synonyms: mu-Nlrc4
• Transgene: Tg(Cd74-Nlrc4*)1Kyas Location: unknown
• Alliance: Tg(Cd74-Nlrc4*)1Kyas page

Transgene origin

• Strain of Origin: C57BL/6N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Cd74-Nlrc4*)1Kyas expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Nlrc4 (MGI:3036243)	The mutation in the mouse gene is the equivalent to an A to C transversion at position 1589 of the human gene.

• Mutation details: The mouse Nlrc4 cDNA with a mutation equivalent to the human A to C transversion at position 1589 in exon 4 (changing a histidine to a proline at position 443) and three HA tags is under the control of an invariant chain promoter. Three lines were created: 1, 2, and 3. Line one shows an approximate 3.1-fold increase in Nlrc4 levels in the spleen compared to endogenous levels. (J:219652)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:219652 Kitamura A, et al., An inherited mutation in NLRC4 causes autoinflammation in human and mice. J Exp Med. 2014 Nov 17;211(12):2385-96
• All: 2 reference(s)