Tg(MMTV-DMTF1_i2)7Kai
Transgene Detail

Summary

• Symbol: Tg(MMTV-DMTF1_i2)7Kai
• Name: transgene insertion 7, Kazushi Inoue
• MGI ID: MGI:5698356
• Synonyms: MMTV-DMP1beta, MMTV-DMP1betaV5His
• Transgene: Tg(MMTV-DMTF1_i2)7Kai Location: unknown
• Alliance: Tg(MMTV-DMTF1_i2)7Kai page

Transgene origin

• Strain of Origin: FVB/NJ

Transgene description

• Transgene Type: Transgenic (Epitope tag, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(MMTV-DMTF1_i2)7Kai expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  DMTF1 (9988)

  Dmtf1

  (MGI:1344415)

  Transgene expresses isoform 2 known as beta.

• Mutation details: The human DMTF1 beta (isoform 2) cDNA with V5 and 6x His tags is under the control of the MMTV-LTR promoter. Four lines were established: 7, 10, 13, and 22, founder line 7 is a representative line. The primary investigator indicates that phenotype is similar in all lines. Western blot and qRT-PCR analyses confirmed expression of protein and mRNA in the mammary glands. (J:220608)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:220608 Maglic D, et al., DMP1beta, a splice isoform of the tumour suppressor DMP1 locus, induces proliferation and progression of breast cancer. J Pathol. 2015 May;236(1):90-102
• All: 1 reference(s)