Tg(Prnp-MAPT*R406W)21807Dwst
Transgene Detail

Summary

• Symbol: Tg(Prnp-MAPT*R406W)21807Dwst
• Name: transgene insertion 21807, David Westaway
• MGI ID: MGI:5703730
• Synonyms: TgTauR406W
• Transgene: Tg(Prnp-MAPT*R406W)21807Dwst Location: unknown
• Alliance: Tg(Prnp-MAPT*R406W)21807Dwst page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-MAPT*R406W)21807Dwst expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MAPT (4137)

  Mapt	(MGI:97180)

• Mutation details: The Syrian hamster prion protein promoter drives the expression of the longest form of the human four-repeat tau with the R406W mutation. Lines 21807, 21783, and 21768 were established. RT-PCR confirmed expression of mRNA in the brain and Western blot analysis shows that expression level is about 80% that of the endogenous mouse levels. (J:95971)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:95971 Ikeda M, et al., Accumulation of filamentous tau in the cerebral cortex of human tau R406W transgenic mice. Am J Pathol. 2005 Feb;166(2):521-31
• All: 2 reference(s)