Dp(16Lipi-Zbtb21)1TybEmcf Cytogenetic Marker Detail

Summary

• Symbol
  Dp(16Lipi-Zbtb21)1TybEmcf
• Name
  duplication, Chr 16, Victor Tybulewicz and Elizabeth M C Fisher 1

• Feature Type
  chromosomal duplication
• IDs
  MGI:5703853

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 16, Syntenic

Human Diseases

• Diseases
  1 with Dp(16Lipi-Zbtb21)1TybEmcf mouse models

Human Disease

Mouse Models

Down syndrome

IDs

Down syndrome      

DOID:14250
ICD10CM:Q90
ICD9CM:758.0
MESH:D004314
NCI:C2993
OMIM:190685
ORDO:870
UMLS_CUI:C0013080

View 1 model

Mouse Models

Human Disease Modeled: Down syndrome

Allelic Composition	Genetic Background	Reference	Phenotypes
Dp(16Lipi-Zbtb21)1TybEmcf/0	B6JNimr.129P2-Dp(16Lipi-Zbtb21)1TybEmcf/Nimr	J:227899	View

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  1 with disease annotations

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  10 phenotypes from 1 allele in 1 genetic background
  14 phenotype references
  

• All Mutations and Alleles
  1
• Targeted
  1
• Find Mice (IMSR)
  3 strains or lines available

References

• Summaries
  All 14

  Diseases 1

  Phenotypes 14
• Earliest
  J:227899 Lana-Elola E, et al., Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel. Elife. 2016 Jan 14;5:e11614
• Latest
  J:345472 Lana-Elola E, et al., Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome. Sci Transl Med. 2024 Jan 24;16(731):eadd6883